Performance
0.6% Acetic Acid
10-vial kit · lyophilized
From$96
ViewPT-141
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from the Melanotan-II backbone with a hydroxyl group replacing the C-terminal amide. It acts…
$577per kit · lyophilized
Qty
1
$577Purity99.0%
HPLC verified · MS confirmedFormulaC₅₀H₆₈N₁₄O₁₀
Mol. Weight1025.2 g/mol
Half-Life~2.7 hours
FormLyophilized powder
CAS189691-06-3
CoA Included3rd-party testedFor Research Use Only
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from the Melanotan-II backbone with a hydroxyl group replacing the C-terminal amide. It acts on MC1R, MC3R, MC4R, and MC5R subtypes in the central nervous system. Research has investigated its role in hypothalamic arousal pathways, vascular tone modulation, and peripheral inflammatory signaling via MC receptor networks.
Research Highlights
- Central MC4R agonism activates hypothalamic arousal and vascular response pathways
- Peripheral anti-inflammatory effects via MC1R and MC3R in macrophage models
- No direct vascular activity — CNS-mediated mechanism distinct from PDE5 inhibitors
- MC receptor distribution mapping across hypothalamic nuclei well characterized
Key References
1
Bremelanotide: an overview of preclinical CNS effects
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