Catalog/Recovery/TB-500

TB-500

TB-500 is a synthetic analogue of the C-terminal fragment (amino acids 17–23) of Thymosin Beta-4, a ubiquitous 43-amino acid actin-sequestering protein. Research has demonstrated…

$82per kit · lyophilized
Qty
1
$82
≥99.0% (HPLC)CoA on every order$100 flat · free over $2,000
Purity99.0%
HPLC verified · MS confirmed
FormulaC₃₂H₅₄N₈O₁₂
Mol. Weight750.8 g/mol
Half-Life~2–3 days
FormLyophilized powder
CAS77591-33-4
CoA Included3rd-party testedFor Research Use Only

TB-500 is a synthetic analogue of the C-terminal fragment (amino acids 17–23) of Thymosin Beta-4, a ubiquitous 43-amino acid actin-sequestering protein. Research has demonstrated its role in promoting cell migration, angiogenesis, and matrix metalloproteinase expression. It has been studied extensively in models of dermal wound healing, cardiac tissue repair, and skeletal muscle regeneration.

Research Highlights

  • Promotes actin polymerization and cell motility in wound healing models
  • Reduces cardiac fibrosis and improves ejection fraction in MI models
  • Anti-inflammatory via downregulation of TNF-α and IL-1β
  • Stimulates angiogenesis through upregulation of VEGF and HIF-1α

Key References

1
Thymosin beta4 accelerates wound healingJ Investig Dermatol Symp Proc · 2010
2
Thymosin beta4 promotes cardiac stem cell migrationJ Mol Cell Cardiol · 2012