Epithalon
Epithalon (Epithalamin/Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally isolated from the pineal gland peptide complex by Prof. Vladimir Khavinson at the St.…
Epithalon (Epithalamin/Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) originally isolated from the pineal gland peptide complex by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation. It has been extensively studied for telomerase activation, elongation of telomeres, regulation of melatonin synthesis, and normalization of circadian rhythm disturbances. It is considered a foundational compound in peptide bioregulation research.
Research Highlights
- Activates telomerase and elongates telomeres in somatic cells in vitro
- Restores melatonin production in aged animals via pinealocyte regulation
- Reduces oxidative stress markers including lipid peroxidation products
- Extended lifespan in fruit fly and murine models in multiple studies
Key References
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