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Catalog/Weight Management/Semaglutide

Semaglutide

Semaglutide is a GLP-1 receptor agonist structurally analogous to native glucagon-like peptide-1, with modifications at positions 8 and 34 and a C-18 fatty acid chain enabling…

$386per kit · lyophilized
Qty
1
$386
≥99.1% (HPLC/MS)CoA on every orderFree shipping on kit orders
Purity99.1%
HPLC verified · MS confirmed
FormulaC₁₈₄H₂₉₁N₄₅O₅₉
Mol. Weight4113.6 g/mol
Half-Life~165 hours
FormLyophilized powder
CAS910463-68-2
CoA Included3rd-party testedFor Research Use Only

Semaglutide is a GLP-1 receptor agonist structurally analogous to native glucagon-like peptide-1, with modifications at positions 8 and 34 and a C-18 fatty acid chain enabling albumin binding and extended half-life. Research has investigated its role in appetite suppression via hypothalamic GLP-1 receptors, regulation of gastric emptying, and downstream effects on lipid metabolism and glucose homeostasis.

Research Highlights

  • Significant body weight reduction in diet-induced obesity murine models
  • Reduces fasting plasma glucose and improves insulin sensitivity markers
  • Hypothalamic GLP-1R activation linked to reduced food intake
  • Cardioprotective signaling pathways under investigation

Key References

1
Once-weekly semaglutide in adults with overweight or obesityN Engl J Med · 2021
2
Semaglutide and cardiovascular outcomes in type 2 diabetesN Engl J Med · 2016